Friday 24 January 2020

From the Wuhan Institute of Immunology

Wuhan Institute Of Virology

Bats in China carry all the ingredients to make a new SARS virus

1 December, 2017

In that outbreak, masked palm civet cats sold in live animal markets passed the virus to people. It wasn’t clear whether civets were the initial source of the virus, or if they caught it from some other animal. Since then, evidence has been building implicating species of horseshoe bats as the origin (SN: 11/30/13, p. 13). Until now, though, coronaviruses isolated from bats were genetically distinct from the one that caused the 2003 outbreak, suggesting that bat strains weren’t the direct ancestor of SARS.
After five years of surveying bats in a cave in southern China’s Yunnan1 Province, Zhengli Shi and colleagues discovered 11 new strains of SARS-related viruses in horseshoe bats (especially in Rhinolophus sinicus). Within the strains, the researchers found all the genes to make a SARS coronavirus similar to the epidemic strain, says Shi, a virologist at the Wuhan Institute of Virology, Chinese Academy of Sciences.

These new strains are more similar to the human version of SARS than were previously identified bat viruses, says Matthew Frieman, a virologist at the University of Maryland in Baltimore.

By analyzing the new viruses’ complete genetic makeup, Shi and her colleagues retraced the steps that might have given rise to the original SARS virus. A few spots in the viruses’ DNA seem particularly prone to rearrangement, so remixing happens often. The study suggests that recombination between viruses has shaped the evolution of SARS, says Baric.

Several of the strains could already grow in human cells, Shi’s team found. That indicates “there’s a chance that the viruses that exist in these bats could jump to people,” Frieman says. “Whether they will or not is anybody’s guess.”

Trying to head off that jump by getting rid of the bats is not a solution, say Frieman and Baric. Bats perform many important ecological tasks, such as eating insects and pollinating some plants. Coronaviruses don’t make bats sick, so studying bats’ immune systems, Frieman says, could give scientists clues about how to fight the illness.

Genetic studies of viruses from horseshoe bats (shown) in one cave in China suggest the animals are reservoirs of SARS coronaviruses. Bats harbor many viruses that can sometimes infect people, including Ebola and Marburg. LIBIAO ZHANG/GUANGDONG INSTITUTE OF APPLIED BIOLOGICAL RESOURCE, CHINA 

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