The US NIH took part in research in Wuhan bioweapons lab into bat virus

This may be the smoking gun that leads to proof of US 

involvement in "gain-of-function" research into bat SARS-

related coronavirus at the Wuhan laboratory where the novel 

coronavirus originated.

A must not be missed discussion from the TruNews team.

CCP VIRUS: WHAT WAS DR. FAUCI'S ROLE IN NIH FUNDING OF WUHAN LAB BAT PROJECT?

Today on TruNews we detail the two studies funded by the U.S. Government conducted with China’s Wuhan Institute of Virology, to research coronavirus in bats and develop “gain-of-function” (GOF) which may have led to the transfer to humans, and the global pandemic. 

Rick Wiles, Doc Burkhart, Edward Szall. Airdate: 04/13/20.

The laboratory at the centre of scrutiny over the pandemic has been carrying out research on bats from the cave which scientists believe is the original source of the devastating outbreak.

Documents obtained by The Mail on Sunday show the Wuhan Institute of Virology undertook coronavirus experiments on mammals captured more than 1,000 miles away in Yunnan – funded by a $3.7 million grant from the US government.

Sequencing of the Covid-19 genome has traced it to bats found in Yunnan's caves.

It comes after this newspaper revealed last week that Ministers here now fear that the pandemic could have been caused by a virus leaking from the institute. 

https://www.dailymail.co.uk/news/article-8211257/Wuhan-lab-performing-experiments-bats-coronavirus-caves.html

Abstract

A large number of SARS-related coronaviruses (SARSr-CoV) have been detected in horseshoe bats since 2005 in different areas of China. However, these bat SARSr-CoVs show sequence differences from SARS coronavirus (SARS-CoV) in different genes (S, ORF8, ORF3, etc) and are considered unlikely to represent the direct progenitor of SARS-CoV. Herein, we report the findings of our 5-year surveillance of SARSr-CoVs in a cave inhabited by multiple species of horseshoe bats in Yunnan Province, China. The full-length genomes of 11 newly discovered SARSr-CoV strains, together with our previous findings, reveals that the SARSr-CoVs circulating in this single location are highly diverse in the S gene, ORF3 and ORF8. Importantly, strains with high genetic similarity to SARS-CoV in the hypervariable N-terminal domain (NTD) and receptor-binding domain (RBD) of the S1 gene, the ORF3 and ORF8 region, respectively, were all discovered in this cave. In addition, we report the first discovery of bat SARSr-CoVs highly similar to human SARS-CoV in ORF3b and in the split ORF8a and 8b. Moreover, SARSr-CoV strains from this cave were more closely related to SARS-CoV in the non-structural protein genes ORF1a and 1b compared with those detected elsewhere. Recombination analysis shows evidence of frequent recombination events within the S gene and around the ORF8 between these SARSr-CoVs. We hypothesize that the direct progenitor of SARS-CoV may have originated after sequential recombination events between the precursors of these SARSr-CoVs. Cell entry studies demonstrated that three newly identified SARSr-CoVs with different S protein sequences are all able to use human ACE2 as the receptor, further exhibiting the close relationship between strains in this cave and SARS-CoV. This work provides new insights into the origin and evolution of SARS-CoV and highlights the necessity of preparedness for future emergence of SARS-like diseases.

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006698

Abstract

The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks in humans. Here we examine the disease potential of a SARS-like virus, SHC014-CoV, which is currently circulating in Chinese horseshoe bat populations1. Using the SARS-CoV reverse genetics system2, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone. The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.

https://www.nature.com/articles/nm.3985

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